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PART 1：PRINCIPLES OF MEDICAL PRACTICE 第1篇：医疗实践原则1

SECTION Ⅰ：HUMANISM AND ETHICS 第Ⅰ部分 人道主义和伦理观2

1 Introduction to Internal Medicine as a Discipline 作为一门学科引入内科学2

2 Clinical Medicine，Clinical Ethics and Physicians'Professionalism 临床医学、临床伦理学和内科医师的职业特性4

SECTION Ⅱ：BASIC MECHANISMS OF HEALTH AND DISEASE 第Ⅱ部分 健康和疾病的基础机制9

3 The Genome Project and Molecular Diagnosis 基因组表达和分子诊断9

4 Cell Growth，Differentiation，and Death 细胞生长、分化和死亡11

5 Principles of the Immune Response 免疫应答的原理14

6 Inflammation：Cells，Cytokines，and Other Mediators 炎症：细胞、细胞因子和其他介质22

7 Mechanisms of Hormone Action 激素作用的机制25

8 Principles of Nutrition 营养学原理33

9 Principles of the Renal Regulation of Fluid and Electrolytes 肾脏调节体液和电解质的原理47

10 Pulmonary Gas Exchange 肺的气体交换54

11 Vascular Biology 血管生物学67

12 Disorders of Lipid Metabolism 脂质代谢病72

13 Pathogenesis of Atherosclerosis 动脉粥样硬化的发病机制94

14 Some Functional Pathways in the Central Nervous System 中枢神经系统中的若干功能性通路99

15 Biology and Genetics of Aging and Longevity 高龄与长寿的生物学和遗传学108

16 Clinical Physiology of Aging 高龄患者的临床生理学118

17 Healthcare Implications of an Aging Society 老龄社会卫生保健问题127

18 Host-Microbe Interaction 宿主-微生物交互作用136

19 Etiology of Malignant Disease 恶性疾病的病因学141

20 Molecular and Cell Biology of Neoplasia 肿瘤的分子生物学和细胞生物学147

21 Epidemiology of Malignant Disease 恶性疾病的流行病学152

22 Prevention of Neoplasia 肿瘤的预防155

23 Transplantation Immunology 移植免疫学159

SECTION Ⅲ：APPROACH TO COMMON PRIMARY CARE ISSUES 第Ⅲ部分 公共初级保健问题的研究164

24 Periodic Health Evaluation 定期健康评价164

25 Preoperative Medical Evaluation 术前医学评价168

26 Immunizations 免疫法169

27 Infectious Disease Prevention in the International Traveler 国际旅客传染病的预防174

28 Cancer Screening and Early Detection 癌症筛选和早期检测179

29 Epidemiology and Prevention of Cardiovascular Disease 心血管疾病的流行病学和预防182

30 Systemic Hypertension 系统性高血压191

31 Approaches to Hypercholesterolemia and Other Abnormal Lipid Profiles 高胆固醇血症和其他脂廓清障碍疾病的处理201

32 Approach to the Patient With Chest Pain(Cardiac and Non-Cardiac) 胸痛(心源性和非心源性)病人的处理214

33 Smoking and Smoking Cessation 吸烟和戒烟219

34 Approach to the Problem of Alcohol Abuse and Dependence 酗酒和酒精依赖问题的处理224

35 Approach to the Problem of Substance Abuse 精神作用物质滥用问题的处理229

36 Obesity 肥胖233

37 Anorexia Nervosa and Eating Disorders 神经性厌食和进食障碍242

38 Approach to the Patient With Unintentional Weight Loss 无意识体重下降病人的处理245

39 Depression，Anxiety，and Other Psychiatric Disorders 抑郁、焦虑和其他心理性疾病247

40 Care of the Dying Patient 濒死病人的护理251

SECTION Ⅳ：PRINCIPLES OF CLINICAL EVALUATION 第Ⅳ部分 临床评估的原则255

41 The Clinical Approach to the Patient 对病人的临床处理255

42 Principles of Clinical Epidemiology 临床流行病学原则257

43 Evidence-Based Medicine 循证医学260

44 Computers in Support of Clinical Decision Making 临床判定的计算机支持264

45 Quality Improvement and Clinical Outcomes Assessment 质量提高和临床效果评定268

46 Assessment of Physician Performance in the New Health Care Environment 在新的保健环境下医师工作的评定272

47 Medical Malpractice and Risk Management 医疗差错和风险的处理措施275

SECTION Ⅴ：RELATED MEDICAL DISCIPLINES 第Ⅴ部分 相关的医疗学科278

48 Adolescent Medicine 青少年医学278

49 Principles of Occupational Medicine 职业病医学原理282

50 Medical Ophthalmology 眼科医学288

51 Medical Otolaryngology 耳鼻喉医学291

52 Principles of Women's Medicine 妇科医学原理299

53 Principles of Sports Medicine 运动医学原理303

54 Principles of Rehabilitation Medicine 康复医学原理308

55 Principles of Clinical Pharmacology 临床药理学原理311

56 Alternative Medicine：Prevalence，Cost，and Usefulness 选择性医疗：流行、费用和有用性319

SECTION Ⅵ ：SELECTED MEDICAL EMERGENCIES 第Ⅵ部分 选择性急症医学324

57 General Principles in the Approach to the Patient with an Acute Emergency 急症病人一般处理原则324

58 Animal Bites and Stings 动物叮咬335

59 Near Drowning 淹溺339

60 Treatment of Anaphylaxis 过敏的治疗342

61 Cardiopulmonary Resuscitation 心肺复苏345

62 Hyperthermia and Hypothermia 高体温和低体温349

63 Ionizing Radiation Injuries 离子辐射损伤352

PART 2：CARDIOLOGY 第2篇 心脏病学359

SECTION Ⅰ：APPROACH TO THE PATIENT WITH CARDIOVASCULAR DISORDERS 第1部分 心血管病病人的处理360

64 Essential Features of the Cardiac History and Physical Examination 心脏病病史及体检的基本特点360

65 Approach to the Patient With Chest Pain 胸痛病人的处理368

66 Approach to the Patient With Heart Failure 心衰病人的处理374

67 Approach to the Patient With Cardiac Arrhythmias 心律失常病人的处理381

68 Approach to the Patient With Heart Murmurs 心脏杂音病人的处理389

69 Approach to the Patient With Syncope 晕厥病人的处理396

70 Approach to the Pregnant Patient With Heart Disease 有心脏病妊娠病人的处理406

71 Approach to the Patient With Hypotension and Shock 低血压和休克病人的处理415

SECTION Ⅱ：DISORDERS OF THE CARDIOVASCULAR SYSTEM 第Ⅱ部分 心血管系统疾病428

72 Coronary Artery Disease 冠状动脉疾病428

73 Acute Myocardial Infarction 急性心肌梗死448

74 Myocardial Diseases 心肌疾病464

75 Tumors of the Heart 心脏肿瘤474

76 Cardiac Arrhythmias 心律失常481

77 Valvular Heart Disease 心脏瓣膜疾病503

78 Congenital Heart Disease in the Adult 成人的先天性心脏病521

79 Pericardial Diseases 心包疾病540

80 Pulmonary Hypertension and Cor Pulmonale 肺动脉高压和心肺疾病547

81 Vascular Medicine 血管病医学554

82 Genetics of the Cardiovascular System 心血管系统的遗传学569

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN CARDIOVASCULAR DISEASES 第Ⅲ部分 心血管疾病的诊断和治疗方式579

83 Cardiovascular Radiology 心血管放射学579

84 Electrocardiography，Exercise Stress Testing，and Ambulatory Monitoring 心电图、运动应激试验和移动监测584

85 Echocardiography 超声心动图597

86 Radionuclide and Magnetic Resonance Techniques 核放射和核共振技术610

87 Diagnostic and Therapeutic Catheterization 诊断性和治疗性导管插入术623

88 Electrophysiologic Testing 电生理学试验635

89 Principles of Cardiac Conditioning and Rehabilitation 心脏条件反射和康复的原理644

90 Clinical Pharmacology of Cardiovascular Drugs 心血管药物的临床药理学651

91 Use of Anticoagulant Drugs 抗凝药物的使用673

92 Principles and Applications of Cardiac Surgery 心脏外科的原理及应用684

93 Medical Management of the Cardiac Transplant Patient 心脏移植病人的药物治疗691

PART 3：GASTROENTEROLOGY 第3篇 胃肠病学697

SECTION Ⅰ：APPROACH TO THE PATIENT WITH DIGESTIVE AND HEPATOBILIARY DISORDERS 第Ⅰ部分 消化及肝胆系统紊乱病人的处理698

94 Approach to the Patient With Dysphagia 吞咽困难病人的处理698

95 Approach to the Patient With Noncardiac Chest Pain 非心脏性胸痛病人的处理702

96 Approach to the Patient With Abdominal Pain 腹痛病人的处理707

97 Approach to the Patient With Acute Abdomen 急腹症病人的处理718

98 Approach to the Patient With Nausea and Vomiting 恶心和呕吐病人的处理729

99 Approach to the Patient With Diarrhea 腹泻病人的处理738

100 Approach to the Patient With Constipation，Fecal Incontinence，and Gas 便秘、大便失禁和胀气病人的处理755

101 Approach to the Patient With an Abdominal or Rectal Mass 腹部或直肠肿物病人的处理763

102 Approach to the Patient With Gastrointestinal Bleeding 胃肠道出血病人的处理770

103 Approach to the Patient With Jaundice 黄疸病人的处理782

104 Approach to the Patient With Abnormal Liver Chemistries 肝化学异常病人的处理791

105 Approach to the Patient With Complications of Chronic Liver Disease and Fulminant Hepatic Failure 慢性肝病和暴发性肝衰竭并发症病人的处理801

SECTION Ⅱ A：DISORDERS OF THE ALIMENTARY TRACT 第ⅡA部分 消化道疾病813

106 Diseases of the Esophagus 食道疾病813

107 Gastroduodenal Ulcer Disease and Gastritis 胃十二指肠溃疡病和胃炎824

108 Motor Disorders of the Gastrointestinal Tract 胃肠道动力功能障碍844

109 Irritable Bowel Syndrome 肠易激惹综合征851

110 Disorders of Digestion and Absorption 消化和吸收功能障碍856

111 Inflammatory Bowel Disease 肠道炎性疾病876

112 Mesenteric Vascular Diseases 肠系膜血管病896

113 Gastrointestinal Infections 胃肠道感染905

114 Gastrointestinal Diseases With an Immune Basis 与免疫有关的胃肠道疾病917

115 Upper Gastrointestinal Neoplasms 上胃肠道肿瘤925

116 Colorectal Neoplasia 结肠直肠肿瘤932

SECTION Ⅱ B：DISORDERS OF THE PANCREAS，LIVER，AND BILIARY TRACT 第ⅡB部分 胰腺、肝脏和胆道系统疾病943

117 Pancreatitis 胰腺炎943

118 Pancreatic Cancer and Gut Neuroendocrine Tumors 胰腺癌和肠道神经内分泌肿瘤961

119 Viral Hepatitis 病毒性肝炎970

120 Autoimmune Hepatitis and Primary Biliary Cirrhosis 自身免疫性肝炎和原发性胆汁性肝硬化978

121 Alcoholic Liver Diseases 酒精性肝病984

122 Drug-Induced Hepatic Injury 药物导致的肝损害996

123 Metabolic，Granulomatous，and Infiltrative Disorders of the Liver 肝脏代谢性、肉芽肿性和浸润性疾病1011

124 Gallstones and Cholecystitis 胆石症和胆囊炎1017

125 Biliary Tract Disease 胆道疾病1025

126 Hepatobiliary Neoplasms 肝胆肿瘤1032

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN DIGESTIVE AND HEPATOBILIARY DISORDERS 第Ⅲ部分 消化和肝胆系统疾病的诊断和治疗方式1040

127 Endoscopic Diagnosis and Therapy 内镜诊断与治疗1040

128 Abdominal and Alimentary Tract Imaging and Interventional Radiology 腹部和消化道造影及介入放射学1049

129 Diagnostic Tests in Gastrointestinal Motility and Physiology 胃肠动力学和生理学的诊断性试验1055

130 Parenteral and Enteral Nutrition 肠外和肠内营养1062

131 Laproscopic Surgery for Gastrointestinal Disorders 胃肠道疾病的腹腔镜外科学1074

132 Liver Transplantation 肝脏移植1082

PART 4：NEPHROLOGY 第4篇 肾脏病学1091

SECTION Ⅰ：APPROACH TO THE PATIENT WITH RENAL AND ELECTROLYTE DISORDERS 第Ⅰ部分 肾和电解质功能紊乱病人的处理1092

133 Approach to the Patient With Renal Disease 肾脏病病人的处理1092

134 Approach to the Patient With Hematuria 血尿病人的处理1095

135 Approach to the Patient With Proteinuria and Nephrotic Syndrome 蛋白尿和肾病综合征病人的处理1098

136 Approach to the Patient With Dysuria and Pyuria 排尿困难和脓尿病人的处理1105

137 Approach to the Patient With Polyuria or Nocturia 多尿或夜尿病人的处理1108

138 Approach to the Patient With Urinary Retention and Obstruction 尿潴留和尿道梗阻病人的处理1112

139 Approach to the Patient With Nephrolithiasis 肾结石病人的处理1119

140 Approach to the Patient With Oliguriaand Acute Renal Failure 少尿和急性肾衰竭病人的处理1124

141 Approach to the Patient With Chronic Renal Failure 慢性肾衰竭病人的处理1133

142 Approach to the Patient With Volume Depletion and Dehydration 血容量减少和脱水病人的处理1146

143 Approach to the Patient With Edema 水肿病人的处理1148

144 Approach to the Patient With Hyponatremia 低钠血症病人的处理1150

145 Approach to the Patient With Hypernatremia 高钠血症病人的处理1157

146 Approach to the Patient With Hypokalemia 低钾血症病人的处理1162

147 Approach to the Patient With Hyperkalemia 高钾血症病人的处理1167

148 Approach to the Patient With Altered Magnesium Concentration 血镁浓度改变病人的处理1172

149 Approach to the Patient With Acid-Base Abnormalities 酸碱平衡紊乱病人的处理1176

SECTION Ⅱ：DISORDERS OF THE KIDNEY 第Ⅱ部分 肾脏疾病1191

150 Immune-Mediated Glomerulopathies 免疫介导的肾小球病1191

151 Tubulointerstitial Diseases 肾小管间质性疾病1208

152 Vascular Diseases of the Kidney 肾脏血管疾病1213

153 Diabetes and the Kidney 糖尿病和肾脏1218

154 Dysproteinemias and the Kidney 蛋白异常血症和肾脏1223

155 Renal Tubular Acidosis and Fanconi Syndrome 肾小管性酸中毒和范科尼综合征1228

156 Renal Cysts and Cystic Diseases 肾囊肿和囊性疾病1232

157 Hereditary Nephropathies 遗传性肾病1235

158 Obstructive Nephropathy 梗阻性肾病1238

159 Renal Lithiasis 肾结石1243

160 Tumors of the Kidney，Ureter，and Bladder 肾脏、输尿管和膀胱肿瘤1248

161 Congenital Anomalies of the Kidney，Ureter，and Bladder 先天性肾脏、输尿管和膀胱异常1254

162 Pregnancy，the Kidney，and Hypertension 妊娠、肾脏和高血压1260

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN RENAL AND ELECTROLYTE DISEASES 第Ⅲ部分 肾脏疾病和电解质紊乱的诊断和治疗方式1266

163 Laboratory Evaluation of Renal Disorders 肾脏疾病的实验室评价1266

164 Renal Biopsy and Treatment of Glomerular Disease 肾活组织检查和肾小球疾病的治疗1273

165 Renal Substitution Treatment in Acute and Chronic Renal Failure 急性和慢性肾功能衰竭患者的肾替代治疗1290

166 Renal Transplantation 肾移植1297

167 Adjustment of Drug Dosage in Patients With Renal Insufficiency 肾功能不全患者药物剂量的调整1304

PART 5：RHEUMATOLOGIC，ALLERGIC，AND DERMATOLOGIC DISEASES 第5篇：风湿性疾病、变应性疾病和皮肤病1315

Rheumatology and Allergy 风湿病学和变态反应1316

SECTION Ⅰ：APPROACH TO THE PATIENT WITH RHEUMATOLOGIC AND ALLERGIC DISORDERS 第Ⅰ部分 风湿性疾病和变应性疾病患者的治疗1316

168 Approach to the Patient With Musculoskeletal Complaints 肌肉骨骼疾病患者的治疗1316

169 Approach to the Patient With Pain in One or a Few Joints 单关节痛或多关节痛患者的治疗1320

170 Approach to the Patient With Polyarthritis or Generalized Musculoskeletal Pain 多关节炎或全身肌肉骨骼痛患者的治疗1324

171 Approach to the Patient With Back Pain 背痛患者的治疗1331

172 Approach to the Patient With Anergy 无反应性患者的治疗1338

173 Approach to the Patient With Allergy 变态反应患者的治疗1340

SECTION Ⅱ：DISORDERS OF THE RHEUMATOLOGIC AND ALLERGIC SYSTEMS 第Ⅱ部分 风湿性和变态反应性系统的疾病1347

174 Rheumatoid Arthritis 类风湿关节炎1347

175 Osteoarthritis and Polychondritis 骨关节炎和多软骨炎1359

176 Spondyloarthropathies 脊椎关节病1364

177 Crystal-Induced Synovitis 结晶诱导性滑膜炎1370

178 Systemic Lupus Erythematosus and Overlap Syndromes 系统性红斑狼疮和重叠综合征1375

179 Scleroderma and Raynaud's Syndrome 硬皮病和雷诺综合征1392

180 Idiopathic Inflammatory Myopathies 特发性炎性肌病1399

181 Vasculitis：Its Many Forms 血管炎：多种形式1404

182 Infectious Arthritis 感染性关节炎1418

183 Lyme Disease 莱姆病1424

184 Infiltrative，Neoplastic，and Endocrinologic Causes of Musculoskeletal Complaints 肌肉骨骼疾病的浸润性、瘤性和内分泌性因素1431

185 Fibromyalgia(Fibrositis)，Chronic Fatigue Syndrome，Bursitis，and Other Nonarticular Rheumatic Complaints 纤维肌痛(肌风湿病)、慢性疲劳综合征、滑囊炎和其他非关节性风湿病1436

186 Heritable Disorders of Connective Tissue 遗传性结缔组织疾病1439

187 Inherited Deficiencies of Complement and Immunoglobulins 先天性补体和免疫球蛋白缺乏1445

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN RHEUMATOLOGIC AND ALLERGIC DISEASES 第Ⅲ部分 风湿性疾病和变态反应性疾病的诊断和治疗方式1451

188 Use of Laboratory Tests in Rheumatic and Immunologic Diseases 风湿性和免疫性疾病实验室检查的应用1451

189 Arthroscopy 关节镜检查1458

190 Imaging Techniques for Rheumatologic Diagnosis 诊断风湿病的显像技术1460

SECTION Ⅰ：APPROACH TO THE PATIENT WITH DERMATOLOGIC DISEASES 第Ⅰ部分 皮肤病患者的治疗1469

191 Approach to the Patient With Skin Lesions 皮肤损害患者的治疗1469

Dermatology 皮肤病学1469

192 Approach to the Patient With Alopecia or Balding 脱发或秃头患者的治疗1478

SECTION Ⅱ：DISORDERS OF THE DERMATOLOGIC SYSTEMS 第Ⅱ部分 皮肤系统的疾病1481

193 Psoriasis，Lichen Planus，and Pityriasis Rosea 银屑病、扁平苔藓和玫瑰糠疹1481

194 Infections of Skin 皮肤感染1486

195 Bullous Diseases of Skin and Mucous Membranes 皮肤和黏膜大疱性疾病1490

196 Atopic and Contact Dermatitis 特异反应性和接触性皮炎1494

197 Allergic Urticaria and Erythema Multiforme 变应性荨麻疹和多形红斑1496

198 Approach to the Management of Skin Cancer 皮肤癌的治疗方法1499

199 Cutaneous Reactions to Drugs 皮肤对药物的反应1503

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN DERMATOLOGIC DISEASES 第Ⅲ部分 皮肤病的诊断和治疗方式1508

200 Dermatologic Diagnosis：Fundamentals for the Internist 皮肤病诊断：内科医师遵循的基本原则1508

PART 6：ONCOLOGY AND HEMATOLOGY 第6篇 肿瘤学和血液学1521

SECTION Ⅰ：APPROACH TO THE PATIENT WITH ONCOLOGIC AND HEMATOLOGIC DISORDERS 第Ⅰ部分 肿瘤和血液病患者的治疗1522

201 Approach to the Patient With Lymphadenopathy 淋巴结病患者的治疗1522

202 Approach to the Patient With Splenomegaly 脾肿大患者的治疗1530

203 Approach to the Patient With a Mediastinal Mass 纵隔肿物患者的治疗1535

204 Approach to the Patient With Superior Vena Cava Syndrome 上腔静脉综合征患者的治疗1540

205 Approach to the Patient With a Palpable Breast Mass and/or An Abnormal Mammogram 可触知的乳房肿块和(或)乳房X射线照片异常患者的治疗1543

206 Approach to the Patient With a Testicular Mass 睾丸肿物患者的治疗1551

207 Approach to the Patient With a Prostate Nodule or Elevated Prostate-Specific Antigen Level 前列腺小瘤和前列腺特异性抗原水平增高患者的治疗1553

208 Approach to the Patient With an Adnexal Mass 附件肿物患者的治疗1556

209 Approach to the Patient With an Abnormal Papanicolaou Smear 巴帕尼科拉乌涂片异常患者的治疗1562

210 Approach to the Patient With A Pathologic Fracture 病理性骨折患者的治疗1567

211 Approach to the Patient With Anemia 贫血患者的治疗1570

212 Approach to the Patient With Leukopenia 白细胞减少症患者的治疗1575

213 Approach to the Patient With Thrombocytopenia 血小板减少症患者的治疗1582

214 Approach to the Patient With Pancytopenia 全血细胞减少患者的治疗1589

215 Approach to the Patient With an Elevated Hemoglobin Level 高血红素患者的治疗1594

216 Approach to the Patient With Leukocytosis 白细胞增多患者的治疗1598

217 Approach to the Patient With Thrombocytosis 血小板增多症患者的治疗1601

218 Approach to the Patient With Bleeding 出血患者的治疗1606

219 Approach to the Patient With Thrombosis 血栓症患者的治疗1614

SECTION Ⅱ：DISORDERS OF ONCOLOGY AND HEMATOLOGY 第Ⅱ部分 肿瘤学和血液学疾病1618

220 Breast Cancer 乳癌1618

221 Gynecologic Malignancies 妇科恶性肿瘤1634

222 Germ Cell Malignancies in Men 男性恶性生殖细胞瘤1639

223 Prostate Cancer 前列腺癌1644

224 Sarcomas of Soft Tissue and Bone 软组织肉瘤和骨肉瘤1648

225 Epithelial Malignancies of the Head and Neck 头颈部恶性上皮肿瘤1653

226 Cancer of Unknown Primary Origin 基本起源不明的癌症1659

227 Acute Leukemias 急性白血病1663

228 Chronic Leukemias 慢性白血病1672

229 Myelodysplastic Syndrome 骨髓增生异常综合征1676

230 Aplastic Anemia and Bone Marrow Failure Syndromes 再生障碍性贫血和骨髓衰竭综合征1680

231 Myeloproliferative Disorders：Polycythemia Vera，Thrombocythemia，and Myelofibrosis 骨髓增生性疾病：真性红细胞增多症、血小板增多症和骨髓纤维化1684

232 Hodgkin's Disease 霍奇金病1689

233 Non-Hodgkin's Lymphomas 非霍奇金淋巴瘤1694

234 Plasma Cell Disorders 浆细胞病1700

235 Amyloidosis 淀粉样变性1707

236 Waldenstr？m's Macroglobulinemia 瓦尔登斯特伦巨球蛋白血症1710

237 Inherited Disorders of Blood Coagulation 遗传性血液凝固疾病1712

238 Acquired Disorders of Blood Coagulation 后天性血液凝固疾病1718

239 Disorders of Platelet Function 血小板功能障碍1723

240 Thrombotic Disorders 血栓性疾病1733

241 Hemoglobinopathies 血红蛋白病1740

242 Iron Deficiency and Iron Loading Anemias 缺铁性贫血和铁负荷性贫血1753

243 Megaloblastic Anemias 巨幼细胞贫血1758

244 Hemolytic Anemias 溶血性贫血1769

245 Sickle Cell Anemia 镰状细胞贫血1788

246 Anemia of Chronic Disease 慢性病诱发的贫血1794

247 Paraneoplastic Syndromes 副癌综合征1797

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN ONCOLOGIC AND HEMATOLOGIC DISORDERS 第Ⅲ部分 肿瘤和血液病的诊断和治疗方式1801

248 Imaging in Oncology 肿瘤显像术1801

249 Pathology and Cytology 病理学和细胞学1806

250 Tumor Markers 肿瘤标记1811

251 Molecular Diagnosis of Cancer 癌症的分子诊断1815

252 Principles of Surgical Oncology 外科肿瘤学原则1825

253 Principles of Radiation Oncology 放射肿瘤学原则1830

254 Principles of Chemotherapy and Hormonal Therapy 化学疗法和激素疗法的原则1835

255 Principles of Biologic Therapy 生物学疗法的原则1849

256 Hematopoietic Growth Factors 造血生长因子1854

257 Blood Types，Tissue Typing，and Transfusion of Blood Products 血型、组织配型和血制品输注1858

258 Hematopoietic Stem Cell Transplantation 造血干细胞移植1865

259 Anticoagulant and Fibrinolytic Therapy 抗凝和纤溶疗法1872

260 Cancer Pain Management 癌痛治疗1875

261 Antiemetic Treatment 止吐治疗1880

262 Design and Conduct of Cancer Clinical Trials 癌症临床试验的设计与实施1883

PART 7：INFECTIOUS DISEASES AND AIDS 第7篇 传染病和艾滋病1887

SECTION Ⅰ：APPROACH TO THE PATIENT WITH INFECTIOUS DISEASES 第Ⅰ部分 传染病患者的治疗1888

263 Approach to the Patient With Cellulitis and Other Soft-Tissue Infections 蜂窝织炎和其他软组织感染患者的治疗1888

Infectious Diseases 传染病1888

264 Intra-Abdominal Abscess：Diagnosis and Management 腹腔脓肿：诊断和处理1895

265 Approach to the Patient With Osteomyelitis 骨髓炎患者的治疗1900

266 Approach to the Febrile Patient 发热患者的治疗1906

267 Approach to Infection in the Immunocompromised Host 免疫妥协宿主感染的治疗1911

268 Approach to the Patient With Bacteremia and Sepsis 菌血症和败血症患者的治疗1918

269 Approach to the Patient With Recurrent Infections 复发性感染患者的治疗1926

SECTION Ⅱ：INFECTIOUS DISEASES 第Ⅱ部分 传染病1931

270 Endocarditis，Intravascular Infections，Pericarditis and Myocarditis 心内膜炎、血管内感染、心包炎和心肌炎1931

271 Approach to Infections of the Genitourinary Tract，Including Perinephric Abscess and Prostatitis 泌尿生殖道感染的治疗，包括肾周脓肿和前列腺炎1941

272 Sexually Transmitted Diseases and Genital Tract Infections 性传播疾病和生殖道感染1948

273 Surgical Infections，including Burns and Postoperative Infections 外科感染，包括烧伤和术后感染1957

Bacterial Infections 细菌性感染1961

274 Staphylococcal Infections 葡萄球菌感染1961

275 Streptococcal Infections 链球菌感染1965

276 Anthrax 炭疽热1978

277 Listeria and Erysipeloid Infections 李斯特菌感染和类丹毒感染1980

278 Corynebacterial Infections 棒状杆菌感染1984

279 Meningococcal Infections 脑膜炎球菌感染1986

280 Gonococcal Infections 淋球菌感染1990

281 Salmonellosis 沙门菌病1997

282 Shigellosis 志贺细菌性痢疾2000

283 Infections Caused by Vibrio and Campylobacter Species 由弧菌属和弯曲杆菌属引起的感染2005

284 Infection Caused by Heliobacter pylori 由幽门螺杆菌引起的感染2012

285 Brucellosis，Tularemia，Pasteurellosis，and Yersiniosis 布鲁菌病、土拉菌病、巴斯德菌病和耶尔森菌病2015

286 Infections Caused by Hemophilus and Bordetella Species 由嗜血杆菌属和博代杆菌属引起的感染2022

287 Legionellosis 军团病2028

288 Chancroid and Granuloma Inguinale 软下疳和腹股沟肉芽肿2032

289 Bartonellosis 巴尔通体病2034

290 Clostridial Infections 梭状芽胞杆菌感染2036

291 Infections Caused by Nonclostridial Anaerobes 由非梭状厌氧菌引起的感染2041

292 Cat-Scratch Disease，Bacillary Angioimatosis，and Peliosis Hepatitis 猫抓病、杆菌性血管瘤病和紫癜性肝炎2050

293 Rat-Bite Fever 鼠咬热2053

Mycobacterial Infections 分枝杆菌感染2055

294 Tuberculosis 结核病2055

295 Nontuberculous Mycobacterial Diseases 非结核分枝杆菌病2065

296 Leprosy 麻风2072

Spirochetal Infections 螺旋体感染2073

297 Syphilis 梅毒2073

298 Nonvenereal Treponematoses：Yaws，Pinta and Endemic Syphilis 非性病性密螺旋体属：雅司病、品他病和地方性梅毒2082

299 Leptospirosis 钩端螺旋体病2085

300 Relapsing Fever 回归热2087

Infections Caused by Fungi and Higher Bacteria 由真菌和高等微生物引起的感染2090

301 Actinomycetes：Nocardiosis，Actinomycetoma，Actinomycosis 放线菌：诺卡放线菌病、放线菌性足分枝菌病、放线菌病2090

302 Infections Caused by Dimorphic Fungi 由双态性真菌引起的感染2094

303 Opportunistic Fungal Infections 机会性真菌感染2099

Rickettsial Infections 立克次体感染2105

304 Infections Caused by Rickettsia，Ehrlicbia Orienta，and Coxiella 由立克次体、东方埃利希体和柯克斯体属引起的感染2105

Mycoplasmal and Chlamydial Infections 支原体和衣原体感染2110

305 Infections Caused by Mycoplasma pneumoniae and the Genital Mycoplasmas 由肺炎支原体和生殖道支原体引起的感染2110

306 Chlamydial Infections 衣原体感染2113

Viral Infections 病毒性感染2118

307 Infections Caused by Arboviruses 由虫媒病毒引起的感染2118

308 Infections Caused by Arenaviruses，Hantaviruses and Filoviruses 由沙粒病毒、汉坦病毒和丝状病毒引起的感染2123

309 Poxvirus Infections 痘病毒感染2136

310 Respiratory Viral Infections 呼吸道病毒感染2138

311 Measles，Mumps，and Rubella 麻疹、流行性腮腺炎和风疹2147

312 Herpes Simplex Virus Infections 单纯疱疹病毒感染2152

313 Cytomegalovirus E-细胞病毒2177

314 Epstein-Barr Virus，and the Infectious Mononucleosis Syndrome E-B病毒和传染性单核细胞增多综合征2179

315 Varicella-Zoster Virus Infection 水痘-带状疱疹病毒感染2185

316 Enterovirus Infections 肠道病毒感染2189

317 Viral Gastroenteritis 病毒性胃肠炎2192

318 Rabies 狂犬病2194

319 Human Papillomaviruses 人乳头状瘤病毒2199

320 Human Herpesvirus 6 人疱疹病毒6型2204

Parasitic Infections 寄生虫感染2206

321 Intestinal Protozoa 肠内原虫2206

322 Malaria 疟疾2210

323 Leishmaniasis 利什曼病2215

324 African and American Trypanosomiasis 非洲和美洲锥虫病2220

325 Babesiosis 巴贝西虫病2226

326 Toxoplasmosis 弓形体病2230

327 Pneumocystosis 肺孢子虫病2236

328 Trichomoniasis 毛滴虫病2240

329 Free-living Amebae Infections：Naegleria，Acanthameba，and Leptomyxids 非寄生性阿米巴感染：耐格里原虫属、棘阿米巴属和细胶丝目2241

330 Introduction to Helminthic Diseases 蠕虫病介绍2245

331 Tissue Nematode Infections 组织线虫感染2245

332 Intestinal Nematodes 肠内线虫2252

333 Cestode Infections 绦虫感染2257

334 Trematode Infections 吸虫感染2262

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN INFECTIOUS DISEASES 第Ⅲ部分 传染病诊断和治疗方式2268

335 Antimicrobial Therapeutic Agents 抗微生物治疗制剂2268

336 Approach to the Treatment of Systemic Fungal Infections 全身性真菌感染的治疗方法2279

337 Antimicrobial Chemoprophylaxis 抗微生物化学药物预防2281

338 Hospital Epidemiology and Infection Control 医院流行病学和感染控制2283

SECTION Ⅰ：APPROACH TO THE PATIENT WITH HIV INFECTION 第Ⅰ部分 HIV感染患者的治疗2293

339 Approach to the Patient With HIV Exposure 接触HIV患者的治疗2293

HIV＆AIDS 人免疫缺陷病毒和艾滋病2293

340 Approach to the Patient With Asymptomatic HIV Infection(and Counseling) 无症状HIV感染患者的治疗(和咨询)2298

341 Approach to the Symptomatic Patient With HIV Infection 有HIV感染症状的患者的治疗2301

342 HIV/AIDS：Approach to the Patient With Pulmonary Disease HIV/AIDS：肺疾病患者的治疗2307

343 HIV/AIDS：Approach to the Patient With Diarrhea and/or Wasting HIV/AIDS：腹泻和/或消瘦患者的治疗2310

344 HIV/AIDS：Approach to the Patient With Neurologic Symptoms HIV/AIDS：有神经学症状的患者的治疗2312

345 Pathogenesis of HIV Infection HIV感染的发病机制2316

SECTION Ⅱ：DISORDERS OF HIV INFECTION 第Ⅱ部分 HIV感染性疾病2320

346 HIV/AIDS：Clinical Considerations HIV/AIDS：临床因素2320

347 Neoplasms in AIDS 艾滋病的肿瘤2328

SECTION Ⅲ：MANAGEMENT，PREVENTION，AND CONTROL 第Ⅲ部分 处理、预防和控制2332

348 Principles of Antiretroviral Treatment and Vaccines 抗逆转录病毒治疗和种植疫苗的原则2332

349 HIV/AIDS：Epidemiology，Prevention and Control HIV/AIDS：流行病学、预防和控制2339

PART 8：PULMONARY AND CRITICAL CARE MEDICINE 第8篇：肺部和重症护理医学2343

SECTION Ⅰ：APPROACH TO THE PATIENT WITH RESPIRATORY DISEASE OR CRITICAL ILLNESS 第Ⅰ部分 呼吸系统疾病或危重症疾病患者的治疗2344

350 Approach to the Patient With Hypoxemia 低氧血症患者的治疗2344

351 Approach to the Patient With Dyspnea 呼吸困难患者的治疗2349

352 Approach to the Patient With Cough 咳嗽患者的治疗2354

353 Approach to the Patient With Hemoptysis 咯血患者的治疗2361

354 Approach to the Cri tically Ill Patient 病危患者的治疗2366

355 Management of the Critically Ill Patient With Multiple Organ Dysfunction 多器官功能不全的病危患者的处理2369

356 Approach to the Patient With Acute Respiratory Failure 急性呼吸衰竭患者的治疗2377

357 Approach to the Management of the Patient With Acute Respiratory Distress Syndrome 急性呼吸窘迫综合征患者的治疗2383

358 Approach to the Patient With Pleural Disease 胸膜疾病患者的治疗2389

359 Approach to the Patient With a Solitary Pulmonary Nodule 单发肺小结节患者的治疗2399

360 Approach to the Patient With Interstitial Lung Disease 间质性肺疾病患者的治疗2403

361 Approach to the Patient With Suspected Pneumonia 可疑肺炎患者的治疗2412

362 Evaluation of Pulmonary Disease in the Immunocompromised Host 免疫抑制宿主的肺部疾病评估2419

SECTION Ⅱ： DISORDERS OF THE RESPIRATORY SYSTEM 第Ⅱ部分 呼吸系统疾病2427

363 Asthma 哮喘2427

364 Chronic Obstructive Pulmonary Disease 慢性阻塞性肺疾病(COPD)2433

365 Bronchiectasis 支气管扩张2439

366 Diseases of the Upper Airway 上呼吸道疾病2443

367 Lung Abscess 肺脓肿2450

368 Pulmonary Tuberculosis 肺结核2454

369 Bronchopulmonary Aspergillosis 支气管肺曲霉病2460

370 Cystic Fibrosis 囊性纤维化2462

371 Idiopathic Interstitial Pneumonias 特发性间质性肺炎2469

372 Hypersensitivity Pneumonitis 过敏性肺炎2477

373 Sarcoidosis 类肉瘤病2481

374 The Granulomatous Vasculitides 肉芽肿性血管炎2486

375 Occupational Lung Diseases 职业性肺疾病2495

376 Miscellaneous Pulmonary Disease 其他肺部疾病2510

377 Lung Cancer 肺癌2521

378 Pulmonary Thromboembolism 肺血栓栓塞症2531

379 Diseases of the Mediastinum and Chest Wall 纵隔和胸壁疾病2536

380 Diseases of Respiratory Muscles 呼吸肌疾病2539

381 Diseases of Ventillatory Control 通气控制疾病2541

382 Sleep Apnea Syndrome，Hypersomnolence，and Other Sleep Disorders 睡眠呼吸暂停综合征和其他睡眠病症2545

383 Inhalation and Aspiration Syndromes 吸入和吸入综合征2553

384 Diseases of High Altitude 高原病2559

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES 第Ⅲ部分 诊断和治疗方式2563

385 Essential Points of the Pulmonary History and Physical Examination 肺部疾患史和体格检查的基本要点2563

386 Approach to Imaging of the Chest 胸部显像术的诊断方法2569

387 Pulmonary Function Testing 肺功能试验2579

388 Hemodynamic and Respiratory Monitoring in Critical Care 重症监护的血液动力学监测和呼吸监测2585

389 Diagnostic Procedures in Pulmonary and Critical Care Medicine 肺部和危重症护理医学的诊断性操作2593

390 Respiratory Therapy Techniques 呼吸治疗技术2601

391 Lung Transplantation 肺移植2608

PART 9：ENDOCRINOLOGY，METABOLISM，AND GENETICS 第9篇：内分泌学、新陈代谢和遗传学2617

SECTION Ⅰ：APPROACH TO THE PATIENT WITH ENDOCRINOLOGIC，METABOLIC，AND GENETIC DISORDERS 第Ⅰ部分 内分泌疾病、代谢性疾病和遗传学疾病患者的治疗2618

392 Approach to the Patient With a Thyroid Nodule 甲状腺小结节患者的治疗2618

393 Approach to Menstrual Disorders and Galactorrhea 月经障碍和溢乳的治疗2620

394 Approach to the Patient With Virilization 男性化患者的治疗2623

395 Approach to the Patient With Gynecomastia 男性乳腺发育的治疗2626

396 Approach to the Infertile Male 男性不育的治疗2628

397 Approach to Sexual Dysfunction in the Female 女性性功能障碍的治疗2631

398 Approach to Sexual Dysfunction in the Male 男性性功能障碍的治疗2632

399 Approach to the Patient With Hyperglycemia 高血糖症患者的治疗2635

400 Approach to the Patient With Hypoglycemia 低血糖症患者的治疗2648

401 Approach to the Patient With Flushing 颜面潮红患者的治疗2651

402 Approach to Hypercalcemia and Hypocalcemia 高钙血症和低钙血症的治疗2652

SECTION Ⅱ：DISORDERS OF ENDOCRINOLOGY，METABOLISM，AND GENETICS 第Ⅱ部分 内分泌学、新陈代谢和遗传学疾病2663

403 Disorders of the Hypothalamic and Anterior Pituitary Gland 下丘脑和垂体前叶的疾病2663

404 Disorders of Posterior Pituitary Function 垂体后叶功能紊乱2684

405 Disorders of the Pineal Gland 松果体的病症2691

406 Disorders of the Thyroid Gland 甲状腺的病症2693

407 Adrenal Cortical Disorders 肾上腺皮质疾病2720

408 Adrenal Medullary Disorders 肾上腺髓质疾病2735

409 Endocrinology of the Female 女性内分泌学2740

410 Disorders of Gonadal Function in Men 男性性腺功能紊乱2743

411 Diabetes Mellitus，Types Ⅰ and Ⅱ Ⅰ型和Ⅱ型糖尿病2751

412 Metabolic Bone Disease 代谢性骨病2769

413 Disorders of Carbohydrate Metabolism(Excluding Diabetes) 碳水化合物代谢病症(不包括糖尿病)2784

414 Disorders of Amino Acid Metabolism 氨基酸代谢病症2788

415 Multiple Endocrine Neoplasia 多发性内分泌瘤病2793

416 Genetic Disorders 遗传性疾病2796

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN ENDOCRINOLOGIC，METABOLIC，AND GENETIC DISORDERS 第Ⅲ部分 内分泌学、新陈代谢和遗传学疾病的诊断和治疗方式2812

417 Testing and Evaluation of Pituitary End-Organ Function 垂体终端器官功能试验与评价2812

418 Evaluation of Thyroid Function Tests 甲状腺功能测验的评价2821

419 Human Gene Therapy 人类基因治疗2829

PART 10：NEUROLOGY 第10篇 神经病学2833

SECTION Ⅰ：APPROACH TO THE PATIENT WITH NEUROLOGIC DISEASES 第Ⅰ部分 神经病患者的治疗2834

420 Approach to the Patient With Neurologic Complaints 神经学疾病患者的治疗2834

421 Approach to the Patient With Headache 头痛患者的治疗2836

422 Approach to the Patient With Dizziness and Vertigo 头晕、头昏患者的治疗2844

423 Approach to the Patient With Tumors of the Central Nervous System 中枢神经系统肿瘤患者的治疗2846

424 Approach to the Patient With Impairment of Consciousness 意识障碍患者的治疗2856

425 Approach to the Patient With a Sleep Disorder 睡眠病症患者的治疗2862

426 Approach to the Patient With Seizures 癫痫患者的治疗2864

427 Approach to the Patient With Visual Complaints 视觉疾病患者的治疗2876

428 Approach to the Patient With a Gait Disorder 步态病症患者的治疗2881

429 Approach to the Patient With Abnormal Movements and Tremors 异常动作和震颤患者的治疗2884

430 Approach to the Patient With Disorders of Sensation 感觉异常患者的治疗2888

431 Approach to the Patient With Suspected Infection of the Central Nervous System 中枢神经系统可疑感染患者的治疗2894

SECTION Ⅱ：DISORDERS OF THE NERVOUS SYSTEM 第Ⅱ部分 神经系统疾病2904

432 Cerebrovascular Diseases 脑血管疾病2904

433 Demyelinating Diseases 脱髓鞘病2912

434 Parkinson's Disease and Related Disorders 帕金森病和相关疾病2915

435 Chronic Dementing Conditions 慢性发狂状态2918

436 Cerebellar Degeneration 小脑退化2921

437 Amytrophic Lateral Sclerosis 肌萎缩性(脊髓)侧索硬化2923

438 Huntington's Disease 亨廷顿舞蹈病2926

439 Central Nervous System Poisoning 中枢神经系统中毒2928

440 The Neurologic Complications and Consequences of Ethanol Use and Abuse 饮酒和酗酒引起的神经学病症和影响2933

441 Bacterial Infections of the Nervous System 神经系统细菌感染2936

442 Viral Infections of the Nervous System 神经系统病毒感染2946

443 Slow Virus Infections in the Nervous System，Including AIDS 神经系统慢病毒感染(含AIDS病毒感染)2953

444 Seizures and Epilepsies 癫痫发作和癫痫2958

445 Structural Disorders of the Spinal Column 脊柱的结构病症2972

446 Disorders of the Peripheral Nervous System 周围神经系统的病症2975

447 Mononeuropathies and Entrapment Neuropathies 单神经病和陷夹性神经病2987

448 Muscle Disease 肌肉疾病2991

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN NEUROLOGIC DISEASES 第Ⅲ部分 神经病的诊断和治疗方式2996

449 Lumbar Puncture and Cerebrospinal Fluid Analysis 腰椎穿刺和脑脊液分析2996

450 Electroencephalography and Evoked Potentials 脑电图和激发电位2999

451 Neurophysiology：Nerve Conduction and Electromyography 神经生理学：神经传导和肌电图3000

452 Neuroimaging 神经显像术3004

453 Serologic and Molecular Genetic Diagnoses 血清学和分子遗传学诊断3015

PART 11：GERIATRICS 第11篇：老年病学3019

SECTION Ⅰ：APPROACH TO ASSESSMENT AND MANAGEMENT OF THE ELDERLY PATIENT WITH A MAJOR GERIATRIC PROBLEM COM-PLEX 第Ⅰ部分 对患常见老年病综合征病人的评估和治疗方法3020

454 Diagnosis and Management of the Elderly Patient 老年患者的诊断和处理3020

455 Approach to the Elderly Patient With Hypertension 老年高血压患者的治疗3026

456 Approach to the Elderly Patient With Diabetes 老年糖尿病患者的治疗3032

457 Approach to the Elderly Patient With Dyslipidemia 血脂异常的老年患者的治疗3037

458 Approach to the Elderly Patient With Incontinence 大小便失禁的老年患者的治疗3041

459 Approach to the Elderly Patient With Altered Mental Status 心理状态改变的老年患者的治疗3047

460 Approach to the Elderly Patient With Depression 老年忧郁症患者的治疗3053

461 Approach to the Elderly Patient With Disorders of Fluid and Osmolality Regulations 体液和渗透压调节失常的老年患者的治疗3055

462 Approach to the Elderly Patient With Falls and Impaired Mobility 跌伤和运动障碍的老年患者的治疗3060

463 Approach to the Patient With Pressure Ulcers 压迫性溃疡病患者的治疗3067

464 Approach to the Frail Elderly Patient 老年体弱患者的治疗3069

SECTION Ⅱ：DISORDERS PROMINENT IN GERI-ATRIC MEDICAL PRACTICE 第Ⅱ部分 老年病学医疗实践中常见的病症3074

465 Diagnosis and Management of Osteoporosis in Older Adults 中老年人骨质疏松症的诊断和处理3074

466 Dementia，Including Alzheimer's Disease 痴呆，包括阿尔茨海默病3082

467 Benign Prostatic Hyperplasia/Urinary Obstruction 良性前列腺增生/泌尿系梗阻3085

SECTION Ⅲ：DIAGNOSTIC AND THERAPEUTIC MODALITIES IN THE ELDERLY：SPECIAL ASPECTS AND CONSIDERATIONS 第Ⅲ部分 老年患者的诊断和治疗方式：特殊问题及考虑3091

468 Geriatric Assessment 老年病学评估3091

469 Geriatric Clinical Pharmacology 老年病临床药物学3095

470 Geriatric Clinical Nutrition，Including Malnutrition，Obesity，and Weight Loss 老年病临床营养学，包括营养不良、肥胖症和体重减轻3107

471 Exercise in the Elderly 老年人的运动3114

472 Geriatric Rehabilitation 老年病康复3123

473 Philosophical and Ethical Issues in Geriatrics 老年病学中的哲学和伦理学问题3127